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The Drugging of America: Overprescription

The other day I said I would address the issue of overmedication, and in particular the amazing overuse of anti-hypertensive drugs. Turns out this is a major problem, especially among older Americans and women. In 2017, a quarter of Americans between 65 and 69 were taking at least five prescription drugs for chronic conditions. Between the ages of 70 and 79, that figure rises to nearly half the population. This phenomenon is called “polypharmacy”: the use of five or more drugs.

And it’s not restricted to the elderly. By 2013, the Mayo Clinic reported that 70 percent of Americans were taking one or more prescription drugs, and 20 percent were on five or more prescriptions.

This doesn’t include over-the-counter nostrums, many of which are real, active pharmaceuticals. If you count the pills you can buy off the shelf at your local Walgreen’s, no prescription asked, those figures are undoubtedly much higher.

Overall, women and the elderly are the most over-prescribed. Nearly 1 in 4 women between the ages of 50 and 64 are on antidepressants, according to the Mayo study. Researchers estimate that 25 percent of people ages 65 to 69 take at least five prescription drugs to treat chronic conditions, a figure that jumps to nearly 46 percent for those between 70 and 79. Doctors say it is not uncommon to encounter patients taking more than 20 drugs to treat acid reflux, heart disease, depression or insomnia, and other disorders.

The medicating of America has been increasing at a fast clip. The Mayo study reports, “The percentage of people who took at least one prescription drug in the past month increased from 44 percent in 1999-2000 to 48 percent in 2007-08.” By 2009, spending on prescription drugs had reached $250 billion: 12 percent of total personal health spending in this country.

And folks: that was eight years ago. This abuse has been growing exponentially for decades.

Many of these drugs are inappropriate or ineffective. So many, in fact, that there’s a name for such misuse: PIM, for “potentially inappropriate medication.”

Why should you care?

Because polypharmacy can harm your long-term physical and mental health. It ups the risk of drug duplication, drug interactions, and adverse drug reactions. Research has shown that medication use may be associated with poor functioning and impaired mental capacity among both younger and older people, and side effects of these drugs affect people of all ages.

“Polypharmacy may be problematic for a number of reasons,” says a report in the Journals of Gerontology. “For example it may increase the risk of using potentially inappropriate medications (PIMs) (,), which have been associated with negative effects on long-term physical and cognitive functioning (). Polypharmacy also results in medication nonadherence (,), increased risk of drug duplication, drug–drug interactions () and adverse drug reactions (ADRs) (,,), and higher health care costs (,,). Researchers have also found that medication use may be associated with poor functional status and decreased cognitive capacity among older adults.”

Often one pill leads to another pill leads to another pill. As The Washington Post describes the process:

At least 15 percent of seniors seeking care annually from doctors or hospitals have suffered a medication problem; in half of these cases, the problem is believed to be potentially preventable. Studies have linked polypharmacy to unnecessary death. Older patients, who have greater difficulty metabolizing medicines, are more likely to suffer dizziness, confusion and falls. And the side effects of drugs are frequently misinterpreted as a new problem, triggering more prescriptions, a process known as a prescribing cascade.

The glide path to overuse can be gradual: A patient taking a drug to lower blood pressure develops swollen ankles, so a doctor prescribes a diuretic. The diuretic causes a potassium deficiency, resulting in a medicine to treat low potassium. But that triggers nausea, which is treated with another drug, which causes confusion, which in turn is treated with more medication.

For many patients, problems arise when they are discharged from the hospital on a host of new medications, layered on top of old ones.

Why is this happening?

Almost certainly because of aggressive marketing by Big Pharma to the public (“Ask your doctor about…”) and directly to doctors. As you can imagine, the profit motive here is vast. With the Baby Boom evolving toward a Geezer Boom, we’re looking at potential profits of many billions of dollars. If we’re at $250 billion now, just imagine what these companies can make in the next few years if every Baby Boomer in the country is gulping down upwards of five meds — every day!

Doctors, being human, are as vulnerable to effective marketing and propaganda as the rest of us. Often they do not have time or energy to read journals that report these issues and that may clue them to PIMs — they rely on journal editors to sift the reliable from the unreliable (not necessarily a safe assumption). They often read only a study’s abstract, which may be inconsistent with the data reported in the article.

Pharmaceutical companies spend billions each year to promote their products, but little is said when drugs prove to be harmful or useless. Thus a doctor may not learn that a drug she or he has been prescribing has been found to be less than desirable for patients.

The Australasian Journal of Medicine observed:

It is telling that drug companies are spending billions every year promoting their products. It is also notable that many new drugs are withdrawn within a very short time of their launch. Worryingly, there is sometimes a relative lack of urgency when a drug is clearly shown to be harming patients. For example 19.8 million patients were prescribed five questionable drugs before action was taken to remove them from the market. This included painkillers, anti-histamines, drugs used to treat obesity and anti-hypertensive drugs. Not one of these were lifesaving nor, in many cases, were they the only drugs available for that indication. In another case physicians prescribed a new painkiller to 2.5 million patients with acute pain, even though many well-tested similar drugs were available and the drug was known to elevate liver enzymes. Similarly the rationale for not withdrawing an anti-histamine from the market as soon as researchers clearly identified it as causing deaths has not been explained. It is surprising that the drug was not removed from the market when the adverse effects were identified, but only after the manufacturer had developed a new product to substitute for it.

Medical and biosciences journals publish more than an article a minute. Even if a practicing physician could keep up with that torrent, much of what goes to print leaves a lot to be desired: “. . .only 5% of published papers reached minimum standards of scientific soundness and clinical relevance, and in most journals the figure was less than 1%.”

Much of this material, even though it appears in often-cited journals, is low in quality and ends up being retracted:

In the period from 2000–2010 a total of 788 papers have been retracted, i.e. expunged from the public record. Approximately three-quarters of these papers had been withdrawn because of a serious error; the rest of the retractions were attributed to fraud (data fabrication or falsification). The fakes were more likely to appear in leading publications with a high “impact factor”. The impact factor is a proxy measure of how often research is cited in other peer reviewed journals. More than half (53%) of the faked research papers had been written by a first author who was a “repeat offender”. This was the case in only one in five (18%) of the erroneous papers. At about the same time it was estimated that the number of articles published between 1950 and 2004 that ought to be retracted should have been as many as 100,000 and at least 10,000. The authors further conclude that although high impact journals tend to have fewer undetected flawed articles than their lower-impact peers, even the most vigilant journals potentially host papers that should be retracted.

And scientific publishing is itself a profit-making enterprise. At the least, any scholarly publication must find funding to support its existence, even if it doesn’t generate a profit for the institution that produces it. Hence, sponsorship by pharmaceutical companies and related interests.

Doctors themselves distrust both Big Pharma and many of the research journals that should provide the basis for an evidence-based practice. A discussion forum for medical doctors addressed this issue. Said one commenter, who writes as “Swank Dieter,”

Those who do not read the journals are uninformed. Those who do read them are misinformed. Personally, I do not trust any article that appears in a journal that takes drug company advertising.

An oncologist signing himself as “Dr. Dave” remarks,

Even when I have to come up with crap to feed the insatiable hunger of my residents or Fellowship students I still rarely read the journals cover to cover or worse even the abstracts.

Time is the issue PLUS the quality of the articles has decreased so drastically in 40 years it takes too much time to read the article THEN sit down with paper and pen to decide if the actual stats are valid or if they were slightly nudged to make the outcome fit the title or sponsor.

There used to be a time where if it was written in a prominent journal it was as good as factual but today that assumption is SO inaccurate it is pathetic.
I can remember rounding with my mentor and being grilled on some nonsensical topic and if I was lucky enough to recall a JNEM article or JAMA article I was off the hook since they were bulletproof.

Now if a kid gives me ANY article as support my standardized reply is did you review the details of the article and are you SURE the statistics are actually proper and not sheer modification?

This is not just an American problem. Polypharmacy is a global issue among developed countries. QJM, a respected international journal of internal medicine, reports that in the UK adults over 65 consume a mean of two drugs a day, increasing to 2.5 at age 75. In Northern Italy, over-75s take a mean of 3.5 drugs a day, and in Denmark, four drugs a day. In Europe as in America, more women than men are targeted to take prescribed drugs.

In the UK, QJM continues, 10 percent of over-65s living in the community (as opposed to an institution) take five or more drugs a day, rising to 15 percent among people 75 and older. Yet this is as nothing compared to rates in the United States: as many as 40 percent of Americans over 65 consume five or more drugs a day. This number rises to six to eight drugs a day among those locked up in nursing homes!

So there you have an overview. The problem extends way beyond the so-called “opioid epidemic,” which is a manifestation of this issue. It touches not just people who have become addicted to prescription and street drugs — in some cases as a result of medical treatment. Excessive medication with prescription and nonprescription drugs affects all of us, and the practice is growing.

As I said the other day, the issue is too  large to cover in one post. So, in coming days I’ll address a few other matters:

Watch this space!


Siri, RESET!

Hallelujah, brothers and sisters! A junket to the Mayo Clinic, halfway to Payson from my house, has reset the computer where the blood pressure neurosis is concerned.

In fact I went in to discuss a different issue, which by the time today’s appointment rolled around had resolved itself. However, I decided to traipse out there anyway, because there were other things to chat about. Because I’d made the appointment on short notice, it was with a physician’s assistant and a nurse-practitioner (yahoo! two of ’em) rather than my regular doctor, who having just returned from maternity leave is maxed.

Number one headache (and today that was a literal term) had to do with the blood pressure conundrum. Took the pills out there and explained why I do not want to take the damn things, but also fessed up that yesterday I enjoyed yet another spike in numbers, into the 140s. In fact, the NP got a first reading of 159 over somegawdawful thing, though that came down considerably.

I hate doctor’s offices and I hate medical facilities and I hate having to explain myself to doctors and I’m not there unless stress and pain push me there, so of course whenever I get into one of those places, my blood pressure hovers near the ceiling.

Fortunately, a pair of the Chinese academics sent a new paper to edit yesterday, so I took the laptop with me so I could read copy while cooling my heels in the waiting room. That meant…lo! I also had my whole neurotic log of daily blood pressure readings, complete with weekly averages, an overall average, and a percentage breakdown of figures by high, medium, and low ranges.

I expected this elaborate spreadsheet would just confirm that I’m crazy, so hesitated to show it to her. But to the contrary: she was delighted to get the data. A-n-n-d…she was not at all fazed by the occasional spikes into the 140s. She said it’s the average that matters, and that under 130 is not very threatening, although one would like to keep it as low as possible to protect the kidneys and heart from potential damage.

I pointed out that the American Heart Association (which is partially funded by Big Pharma…) insists that ONE reading in the 140s or above is enough to put you on pills. (The British Health Service, in contrast, states that a consistent pattern of 140+ readings over time is the criterion.) I also pointed out that AHA guidelines recently changed; what used to be designated “moderately elevated” (readings in the 130s) is now considered to be “prehypertension” that must be treated, that readings in the 120s are now the “moderately elevated” range, and that the desired range is now in the 110s. She shrugged that off: clearly not impressed.

She said with an overall average of 128.4/83.3, she probably would not prescribe medication at all. However, she did agree that some of the startling spikes were a concern. And she also agreed that the drug Cardiodoc prescribed (or any of them, for that matter) had the potential to cause some serious dizziness since my BP is often in the low 120s…and even, of late, in the teens. On the other hand, she thought there was a good chance the very small dose would have no side effects at all. She suggested that I simply try the drug on a day that I don’t have to drive anywhere and see what happens. In fact, she proposed that I try it during a time when the numbers are spiking.

I said I’d been told it takes two weeks to take effect. Not so, said she: it’s a 24-hour pill, and if it’s gonna work, it will work within that period. She said it isn’t necessary to get “on” it for any length of time to see what it will do. And if we don’t like the results, the obvious response is simply to…well…stop taking it.


So relieved was I that I decided to stop in my favorite mega-supermarket, which is on the way home from the Mayo, buy a bottle of Cabernet, and take a flying leap off the back end of the wagon. Then, go to bed and sleep away the remaining half the afternoon.

Last night was pretty terrible: after coming home around 10:30 from a choir shindig in a restaurant (nothing like a club soda instead of a glass of wine to make you the life of the party…), the evening BP readings were in the stratosphere. Then — perhaps consequently — I slept badly, woke up at 5 with a hot flash, and found readings that were still elevated by the light of dawn.

Well, the Mayo Lady pointed out that scarfing down a basket of salty French fries after having had nothing to eat since about 2 in the afternoon would tend to jack up one’s blood pressure numbers. I thought that was a long-term effect, not a one-off sort of thing, but apparently restaurant food will do the job on your BP readings right now. Yes, I do know better than to eat that kind of junk, but by 9:30 last night I was too hungry to care.

So I fly in the house, grill a lamb chop and some asparagus and serve those up with some leftover polenta and a tomato and a couple glasses of cheap red wine. Yes!!

Then I stagger into the back of the house, fall into the bed, and sleep for a good two hours. Phone rings; chat with friend; fall back to sleep.

Roll out of the sack along about 5:30. Feed the dogs, pick up the kitchen. Break out the Omron. And this is what happened:

Holy mackerel! And think o’ that: 108/74? 110/72?!!?

Clearly what is missing from my life is red wine…

Seriously: at 10:30 last night the average of six figures was 144/85.8. Less than 24 hours later, all but one of a similar set of figures is under 120.

You can guess what would happen if I took a blood pressure drug when the underlying blood pressure was in that range. I wouldn’t even be able to stand upright.

Do I have a conclusion to draw from this?

Well, yeah: One conclusion is that obsessing over the blood pressure is probably driving my blood pressure up.

The other is, I need to go to the Mayo, not to a doctor in the wild. Mayo Clinic physicians are salaried employees: they have no incentive to overprescribe treatments and medications. Not to be driven crazy or bullied into unnecessary treatment is worth the endless drive through the homicidal traffic.

And finally, what is needed is an occasional glass of wine.



Live and Learn

Little Dog and the Human have been under the weather the past few days. Cassie has given her sore leg a hot spot by licking it. I’ve been sick at my stomach for upwards of a week; starting to wonder if I got into some of that salmonella the press has been dramatizing.

The vet and I collaborated to make things worse for the dog by giving her a couple of doses of an overpriced prescription NSAID called Metacam, which knocked her for a doggy loop. She’s refused to eat for two days, and all day today she could barely wriggle.

Now that the drug is wearing off, though, she’s returning to normal. Just got back from a very zippy doggy-walk.

Personal finance hook

I dreamed up a frugal way to bandage a hot spot on a dog’s leg, by way of discouraging the licking that gives rise to such wounds. Having no gauze or tape in the house, last night I stuck a Bandaid over the sore. To my amazement, she not only didn’t rip it off instantly, by this morning the bandage was still in place. After a while, though, she figured out that she could lick around and under it. With a queasy belly and a ton of work to do this morning, I just didn’t feel like driving through the heat in search of still more stuff to buy.

Stashed in a drawer, what should I find but an athletic bandage made of a slightly tacky, stretchy material-instead of securing it with Velcro or little metal hooks, you just press it together and it sticks to itself. But unlike surgical tape, it doesn’t stick to your skin and pull out your hair-or fur. Perfect.

A bit of a clean cotton ball with a dab antibiotic ointment placed over the sore spot, and then I wrapped the dog’s leg with the sticky athletic bandage. And voilà! After a moment’s annoyance and a small adjustment, she didn’t seem bothered by it. Kept it on all day without trying to chew it off. This evening the limp is about gone and the hot spot looks much better.

Personal finance hook no. 2

If you wouldn’t put it in your mouth, don’t put it in your pet’s. Would I have taken a prescription drug for a minor ache? N-O-O-O-O! So what possessed me to give it to the dog? Especially after a baby aspirin did the job with no problem the other day, for a tiny fraction of the cost. This Metacam stuff can kill the dog’s appetite; cause nausea, diarrhea, and lethargy; and damage the liver. Charming.

Well, we got the appetite loss and the lethargy. Hope that’s all.

It was another bad buy from Big Pharma. If your ailment (or your dog’s) is neither life-threatening nor excruciating, try a nondrug treatment first; then move to an over-the-counter nostrum before rolling out the heavy pharmaceutical armament. Probably the dog needed no painkiller at all, just rest. But if she did need a pill, an inexpensive baby aspirin would have sufficed